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Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation

HMGB1 is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: Deng, Meihong, Scott, Melanie J, Fan, Jie, Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597316/
https://ncbi.nlm.nih.gov/pubmed/30946496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.3MIR1218-497R
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