Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

Proteolytic cleavage of the tumor necrosis factor (TNF) receptor (TNFR) from the cell surface contributes to anti-inflammatory responses and may be beneficial in reducing the excessive inflammation associated with multiple organ failure and mortality during sepsis. Using a clinically relevant mouse...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Deng, Meihong, Loughran, Patricia A., Zhang, Liyong, Scott, Melanie J., Billiar, Timothy R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766373/
https://ncbi.nlm.nih.gov/pubmed/25628461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005548
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