A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes

We and others have previously shown that the inducible nitric-oxide synthase (iNOS) and nitric oxide (NO) are hepatoprotective in a number of circumstances, including endotoxemia. In vitro, hepatocytes are protected from tumor necrosis factor (TNF) α-induced apoptosis via cGMP-dependent and cGMP-ind...

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Detalhes bibliográficos
Main Authors: Chanthaphavong, R. Savanh, Loughran, Patricia A., Lee, Tiffany Y. S., Scott, Melanie J., Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476257/
https://ncbi.nlm.nih.gov/pubmed/22898814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365171
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