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Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice

Energy homeostasis involves central nervous system integration of afferent inputs that coordinately regulate food intake and energy expenditure. Here, we report that adult homozygous TNFα converting enzyme (TACE)-deficient mice exhibit one of the most dramatic examples of hypermetabolism yet reporte...

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Detalhes bibliográficos
Main Authors: Gelling, Richard W., Yan, Wenbo, Al-Noori, Salwa, Pardini, Aaron, Morton, Gregory J., Ogimoto, Kayoko, Schwartz, Michael W., Dempsey, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734496/
https://ncbi.nlm.nih.gov/pubmed/18687778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0775
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