Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice

Energy homeostasis involves central nervous system integration of afferent inputs that coordinately regulate food intake and energy expenditure. Here, we report that adult homozygous TNFα converting enzyme (TACE)-deficient mice exhibit one of the most dramatic examples of hypermetabolism yet reporte...

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Main Authors: Gelling, Richard W., Yan, Wenbo, Al-Noori, Salwa, Pardini, Aaron, Morton, Gregory J., Ogimoto, Kayoko, Schwartz, Michael W., Dempsey, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: The Endocrine Society 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734496/
https://ncbi.nlm.nih.gov/pubmed/18687778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0775
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