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TACE (ADAM17) inhibits Schwann cell myelination
Tumor necrosis factor-α–converting enzyme (TACE; also known as ADAM17) is a proteolytic sheddase that is responsible for the cleavage of several membrane-bound molecules. We report that TACE cleaves neuregulin-1 (NRG1) type III in the epidermal growth factor domain, probably inactivating it (as asse...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291894/ https://ncbi.nlm.nih.gov/pubmed/21666671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2849 |
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