Characterization of DISC Formation and TNFR1 Translocation to Mitochondria in TNF-α–Treated Hepatocytes

Tumor necrosis factor receptor 1 (TNFR1) activation in hepatocytes can trigger apoptotic or inflammatory signaling. The factors that determine which signaling pathway dominates are not clear and are thought to relate to the efficiency of death-inducing signaling complex (DISC) formation. However, th...

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Detalhes bibliográficos
Main Authors: Eum, Hyun-Ae, Vallabhaneni, Raghuveer, Wang, Yinna, Loughran, Patricia A., Stolz, Donna Beer, Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157172/
https://ncbi.nlm.nih.gov/pubmed/21741934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.046
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