Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b(+)Gr-1(+) Myeloid-Derived Suppressor Cells Require HMGB1

Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture c...

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Библиографические подробности
Опубликовано в: :Mediators Inflamm
Главные авторы: Ruan, Xiangcai, Darwiche, Sophie S., Cai, Changchun, Scott, Melanie J., Pape, Hans-Christoph, Billiar, Timothy R.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325468/
https://ncbi.nlm.nih.gov/pubmed/25709155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/458626
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