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Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b(+)Gr-1(+) Myeloid-derived Suppressor Cells
CD137 (4-1BB/tnfrsf9) has been shown to co-stimulate T cells. However, agonistic anti-CD137 monoclonal antibody (mAb) treatment can suppress CD4(+) T cells, ameliorating autoimmune diseases, whereas it induces activation of CD8(+) T cells, resulting in diverse therapeutic activity in cancer, viral i...
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| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The Korean Association of Immunologists
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902672/ https://ncbi.nlm.nih.gov/pubmed/20631881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4110/in.2010.10.3.104 |
| תגים: |
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