Purposeful repurposing: unexpected but not necessarily unwelcome effects of dexmedetomidine

Por Scott, Melanie J.
Publicado no Crit Care Med (2015)

β2-Integrin-induced p38 MAPK Activation Is a Key Mediator in the CD14/TLR4/MD2-dependent Uptake of Lipopolysaccharide by Hepatocytes

Por Scott, Melanie J., Billiar, Timothy R.
Publicado em 2008

Jaks, STATs, Cytokines, and Sepsis

Por Scott, Melanie J., Godshall, Christopher J., Cheadle, William G.
Publicado em 2002

Glutathione and thioredoxin type 1 cooperatively denitrosate HepG2 cells-derived cytosolic S-nitrosoproteins

Por Stoyanovsky, Detcho A., Scott, Melanie J., Billiar, Timothy R.
Publicado em 2013

N-tert-butylmethanimine N-oxide is an efficient spin-trapping probe for EPR analysis of glutathione thiyl radical

Por Scott, Melanie J., Billiar, Timothy R., Stoyanovsky, Detcho A.
Publicado no Sci Rep (2016)

Hepatocytes express functional NOD1 and NOD2 receptors: A role for NOD1 in hepatocyte CC and CXC chemokine production

Por Scott, Melanie J., Chen, Christine, Sun, Qian, Billiar, Timothy R.
Publicado em 2010

Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Nega...

Por Yang, Qin, Stevenson, Heather L., Scott, Melanie J., Ismail, Nahed
Publicado no Am J Pathol (2015)

Immune Activation in the Liver by Nucleic Acids

Por Sun, Qian, Wang, Qingde, Scott, Melanie J., Billiar, Timothy R.
Publicado no J Clin Transl Hepatol (2016)

Inflammasome and Autophagy Regulation: A Two-way Street

Por Qian, Sun, Fan, Jie, Billiar, Timothy R, Scott, Melanie J
Publicado no Mol Med (2017)

Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1 dependent mechanism

Por Scott, Melanie J., Liu, Shubing, Shapiro, Richard A., Vodovotz, Yoram, Billiar, Timothy R.
Publicado em 2009

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling

Por Deng, Meihong, Loughran, Patricia A., Zhang, Liyong, Scott, Melanie J., Billiar, Timothy R.
Publicado no Sci Signal (2015)

Lipopolysaccharide Stimulates p62-Dependent Autophagy-Like Aggregate Clearance in Hepatocytes

Por Chen, Christine, Deng, Meihong, Sun, Qian, Loughran, Patricia, Billiar, Timothy R., Scott, Melanie J.
Publicado em 2014

STAT4 Is Required for Antibacterial Defense but Enhances Mortality during Polymicrobial Sepsis

Por Godshall, Christopher J., Lentsch, Alex B., Peyton, James C., Scott, Melanie J., Cheadle, William G.
Publicado em 2001

A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) α-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1...

Por Chanthaphavong, R. Savanh, Loughran, Patricia A., Lee, Tiffany Y. S., Scott, Melanie J., Billiar, Timothy R.
Publicado em 2012

Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b(+)Gr-1(+) Myeloid-Derived...

Por Ruan, Xiangcai, Darwiche, Sophie S., Cai, Changchun, Scott, Melanie J., Pape, Hans-Christoph, Billiar, Timothy R.
Publicado no Mediators Inflamm (2015)

Caspase 1 Activation Is Protective against Hepatocyte Cell Death by Up-regulating Beclin 1 Protein and Mitochondrial Autophagy in the Setting of Redox Stress

Por Sun, Qian, Gao, Wentao, Loughran, Patricia, Shapiro, Rick, Fan, Jie, Billiar, Timothy R., Scott, Melanie J.
Publicado em 2013

Caspase-1 Is Hepatoprotective during Trauma and Hemorrhagic Shock by Reducing Liver Injury and Inflammation

Por Menzel, Christoph L, Sun, Qian, Loughran, Patricia A, Pape, Hans-Christoph, Billiar, Timothy R, Scott, Melanie J
Publicado em 2011

Lipopolysaccharide Clearance, Bacterial Clearance, and Systemic Inflammatory Responses Are Regulated by Cell Type–Specific Functions of TLR4 during Sepsis

Por Deng, Meihong, Scott, Melanie J., Loughran, Patricia, Gibson, Gregory, Sodhi, Chhinder, Watkins, Simon, Hackam, David, Billiar, Timothy R.
Publicado em 2013

Leukotriene B(4) Receptor (BLT-1) Modulates Neutrophil Influx into the Peritoneum but Not the Lung and Liver during Surgically Induced Bacterial Peritonitis in Mice

Por Scott, Melanie J., Cheadle, William G., Hoth, J. Jason, Peyton, James C., Subbarao, Krishnaprasad, Shao, Wen-Hai, Haribabu, Bodduluri
Publicado em 2004

Metformin improves nonalcoholic fatty liver disease in obese mice via down-regulation of apolipoprotein A5 as part of the AMPK/LXRα signaling pathway

Por Lin, Min-Jie, Dai, Wen, Scott, Melanie J., Li, Rong, Zhang, Yi-Qi, Yang, Yang, Chen, Lu-Zhu, Huang, Xian-Sheng
Publicado no Oncotarget (2017)