Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites

Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites of the inositol phosphate (IP) pathway. Here we reveal that I(1,3,4,6)P(4)...

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I publikationen:Cell Chem Biol
Huvudupphovsmän: McNamara, Dan E., Dovey, Cole M., Hale, Andrew T., Quarato, Giovanni, Grace, Christy R., Guibao, Cristina D., Diep, Jonathan, Nourse, Amanda, Cai, Casey R., Wu, Hong, Kalathur, Ravi C., Green, Douglas R., York, John D., Carette, Jan E., Moldoveanu, Tudor
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588482/
https://ncbi.nlm.nih.gov/pubmed/31031142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.010
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