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Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis upon inhibition of the proteasome. How BOK mediates MOMP is mechanistically unknown. The NMR structure of the BCL-2 core of human BOK reveals a...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6500462/ https://ncbi.nlm.nih.gov/pubmed/29768206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.060 |
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