Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis

The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis upon inhibition of the proteasome. How BOK mediates MOMP is mechanistically unknown. The NMR structure of the BCL-2 core of human BOK reveals a...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Zheng, Janet H., Grace, Christy R., Guibao, Cristina D., McNamara, Dan E., Llambi, Fabien, Wang, Yue-Ming, Chen, Taosheng, Moldoveanu, Tudor
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500462/
https://ncbi.nlm.nih.gov/pubmed/29768206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.060
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