BOK Is a Non-Canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolute required for this process. Here we report that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Llambi, Fabien, Wang, Yue-Ming, Victor, Bernadette, Yang, Mao, Schneider, Desiree M., Gingras, Sébastien, Parsons, Melissa J., Zheng, Janet H., Brown, Scott A., Pelletier, Stéphane, Moldoveanu, Tudor, Chen, Taosheng, Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018360/
https://ncbi.nlm.nih.gov/pubmed/26949185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.026
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