Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites

Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites of the inositol phosphate (IP) pathway. Here we reveal that I(1,3,4,6)P(4)...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: McNamara, Dan E., Dovey, Cole M., Hale, Andrew T., Quarato, Giovanni, Grace, Christy R., Guibao, Cristina D., Diep, Jonathan, Nourse, Amanda, Cai, Casey R., Wu, Hong, Kalathur, Ravi C., Green, Douglas R., York, John D., Carette, Jan E., Moldoveanu, Tudor
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588482/
https://ncbi.nlm.nih.gov/pubmed/31031142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.010
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