MLKL requires the inositol phosphate code to execute necroptosis

Necroptosis is an important form of lytic cell death triggered by injury and infection, yet whether mixed lineage kinase domain-like (MLKL) is sufficient to execute this pathway is unknown. In a genetic selection for human cell mutants defective for MLKL-dependent necroptosis, we identified mutation...

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Publié dans:Mol Cell
Auteurs principaux: Dovey, Cole M., Diep, Jonathan, Clarke, Bradley P., Hale, Andrew T., McNamara, Dan E., Guo, Hongyan, Brown, Nathaniel W., Cao, Jennifer Yinuo, Grace, Christy R., Gough, Peter J., Bertin, John, Dixon, Scott J., Fiedler, Dorothea, Mocarski, Edward S., Kaiser, William J., Moldoveanu, Tudor, York, John D., Carette, Jan E.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994928/
https://ncbi.nlm.nih.gov/pubmed/29883610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.010
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