Herpes Simplex Virus Suppresses Necroptosis in Human Cells

Herpes simplex virus (HSV)1 and HSV2 are significant human pathogens causing recurrent disease. During infection, HSV modulates cell death pathways using the large subunit (R1) of ribonucleotide reductase (RR) to suppress apoptosis by binding to and blocking Caspase 8. Here, we demonstrate that HSV1...

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Détails bibliographiques
Publié dans:Cell Host Microbe
Auteurs principaux: Guo, Hongyan, Omoto, Shinya, Harris, Philip A., Finger, Joshua N., Bertin, John, Gough, Peter J., Kaiser, William J., Mocarski, Edward S.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382104/
https://ncbi.nlm.nih.gov/pubmed/25674983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.003
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