Herpes Simplex Virus Suppresses Necroptosis in Human Cells

Herpes simplex virus (HSV)1 and HSV2 are significant human pathogens causing recurrent disease. During infection, HSV modulates cell death pathways using the large subunit (R1) of ribonucleotide reductase (RR) to suppress apoptosis by binding to and blocking Caspase 8. Here, we demonstrate that HSV1...

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Bibliografiske detaljer
Udgivet i:Cell Host Microbe
Main Authors: Guo, Hongyan, Omoto, Shinya, Harris, Philip A., Finger, Joshua N., Bertin, John, Gough, Peter J., Kaiser, William J., Mocarski, Edward S.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382104/
https://ncbi.nlm.nih.gov/pubmed/25674983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.01.003
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