Sequential Engagement of Distinct MLKL Phosphatidylinositol–Binding Sites Executes Necroptosis

Necroptosis is a cell death pathway regulated by the receptor interacting protein kinase 3 (RIPK3) and the mixed lineage kinase domain-like (MLKL) pseudokinase. How MLKL executes plasma membrane rupture upon phosphorylation by RIPK3 remains controversial. Here, we characterize the hierarchical trans...

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Publicado en:Mol Cell
Autores principales: Quarato, Giovanni, Guy, Cliff S., Grace, Christy R., Llambi, Fabien, Nourse, Amanda, Rodriguez, Diego A., Wakefield, Randall, Frase, Sharon, Moldoveanu, Tudor, Green, Douglas R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769881/
https://ncbi.nlm.nih.gov/pubmed/26853145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.01.011
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