Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites

Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites of the inositol phosphate (IP) pathway. Here we reveal that I(1,3,4,6)P(4)...

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Publicado en:Cell Chem Biol
Main Authors: McNamara, Dan E., Dovey, Cole M., Hale, Andrew T., Quarato, Giovanni, Grace, Christy R., Guibao, Cristina D., Diep, Jonathan, Nourse, Amanda, Cai, Casey R., Wu, Hong, Kalathur, Ravi C., Green, Douglas R., York, John D., Carette, Jan E., Moldoveanu, Tudor
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588482/
https://ncbi.nlm.nih.gov/pubmed/31031142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.010
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