Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a ‘tail switching’ strategy on a piperazinyl azetidine skeleton

Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathological conditions including chronic pain, inflammation...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Chen, Zhen, Mori, Wakana, Deng, Xiaoyun, Cheng, Ran, Ogasawara, Daisuke, Zhang, Genwei, Schafroth, Michael A., Dahl, Kenneth, Fu, Hualong, Hatori, Akiko, Shao, Tuo, Zhang, Yiding, Yamasaki, Tomoteru, Zhang, Xiaofei, Rong, Jian, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Xie, Lin, Kumata, Katsushi, Gou, Yuancheng, Chen, Jingjin, Gu, Shuyin, Bao, Liang, Wang, Lu, Lee Collier, Thomas, Vasdev, Neil, Shao, Yihan, Ma, Jun-An, Cravatt, Benjamin F., Fowler, Christopher, Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581563/
https://ncbi.nlm.nih.gov/pubmed/30829483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01778
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