In vitro and In vivo evaluation of (11)C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies

Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous cannabinoid ligand, 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG levels, resulting in subsequent activation of the endocannabinoid system, and has emerged as a novel therapeutic strategy to treat drug...

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Publicado no:J Med Chem
Main Authors: Cheng, Ran, Mori, Wakana, Ma, Longle, Alhouayek, Mireille, Hatori, Akiko, Zhang, Yiding, Ogasawara, Daisuke, Yuan, Gengyang, Chen, Zhen, Zhang, Xiaofei, Shi, Hang, Yamasaki, Tomoteru, Xie, Lin, Kumata, Katsushi, Fujinaga, Masayuki, Nagai, Yuji, Minamimoto, Takafumi, Svensson, Mona, Wang, Lu, Du, Yunfei, Ondrechen, Mary Jo, Vasdev, Neil, Cravatt, Benjamin F., Fowler, Christopher, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966020/
https://ncbi.nlm.nih.gov/pubmed/29481079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01400
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