Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a ‘tail switching’ strategy on a piperazinyl azetidine skeleton

Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathological conditions including chronic pain, inflammation...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Chen, Zhen, Mori, Wakana, Deng, Xiaoyun, Cheng, Ran, Ogasawara, Daisuke, Zhang, Genwei, Schafroth, Michael A., Dahl, Kenneth, Fu, Hualong, Hatori, Akiko, Shao, Tuo, Zhang, Yiding, Yamasaki, Tomoteru, Zhang, Xiaofei, Rong, Jian, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Xie, Lin, Kumata, Katsushi, Gou, Yuancheng, Chen, Jingjin, Gu, Shuyin, Bao, Liang, Wang, Lu, Lee Collier, Thomas, Vasdev, Neil, Shao, Yihan, Ma, Jun-An, Cravatt, Benjamin F., Fowler, Christopher, Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581563/
https://ncbi.nlm.nih.gov/pubmed/30829483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01778
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