Design, Synthesis and Evaluation of (18)F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) li...

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Publié dans:J Med Chem
Auteurs principaux: Chen, Zhen, Mori, Wakana, Fu, Hualong, Schafroth, Michael A., Hatori, Akiko, Shao, Tuo, Zhang, Genwei, Van, Richard S., Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Wang, Lu, Belov, Vasily, Ogasawara, Daisuke, Giffenig, Pilar, Deng, Xiaoyun, Rong, Jian, Yu, Qingzhen, Zhang, Xiaofei, Papisov, Mikhail I., Shao, Yihan, Collier, Thomas L., Ma, Jun-An, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875603/
https://ncbi.nlm.nih.gov/pubmed/31518130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00936
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