Design, Synthesis and Evaluation of (18)F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) li...

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Publicado no:J Med Chem
Main Authors: Chen, Zhen, Mori, Wakana, Fu, Hualong, Schafroth, Michael A., Hatori, Akiko, Shao, Tuo, Zhang, Genwei, Van, Richard S., Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Wang, Lu, Belov, Vasily, Ogasawara, Daisuke, Giffenig, Pilar, Deng, Xiaoyun, Rong, Jian, Yu, Qingzhen, Zhang, Xiaofei, Papisov, Mikhail I., Shao, Yihan, Collier, Thomas L., Ma, Jun-An, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875603/
https://ncbi.nlm.nih.gov/pubmed/31518130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00936
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