Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[(11)C]methoxyphenethyl)pyridazin-3(2H)-one, a (11)C-labeled D-amino acid oxidase (DAAO) inhibitor for PET imaging

Selective DAAO inhibitors have demonstrated promising therapeutic effects in clinical studies, including clinically alleviating symptoms of schizophrenic patients and ameliorating cognitive function in Alzheimer’s patients with early phase. Herein we report the synthesis and preliminary evaluation o...

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Dades bibliogràfiques
Publicat a:Bioorg Med Chem Lett
Autors principals: Deng, Xiaoyun, Zhang, Yiding, Chen, Zhen, Kumata, Katsushi, Van, Richard, Rong, Jian, Shao, Tuo, Hatori, Akiko, Mori, Wakana, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Murtas, Giulia, Pollegioni, Loredano, Zhang, Ming-Rong, Liang, Steven
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363051/
https://ncbi.nlm.nih.gov/pubmed/32631531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127326
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