Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[(11)C]methoxyphenethyl)pyridazin-3(2H)-one, a (11)C-labeled D-amino acid oxidase (DAAO) inhibitor for PET imaging

Selective DAAO inhibitors have demonstrated promising therapeutic effects in clinical studies, including clinically alleviating symptoms of schizophrenic patients and ameliorating cognitive function in Alzheimer’s patients with early phase. Herein we report the synthesis and preliminary evaluation o...

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Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Deng, Xiaoyun, Zhang, Yiding, Chen, Zhen, Kumata, Katsushi, Van, Richard, Rong, Jian, Shao, Tuo, Hatori, Akiko, Mori, Wakana, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Murtas, Giulia, Pollegioni, Loredano, Zhang, Ming-Rong, Liang, Steven
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363051/
https://ncbi.nlm.nih.gov/pubmed/32631531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127326
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