Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[(11)C]methoxyphenethyl)pyridazin-3(2H)-one, a (11)C-labeled D-amino acid oxidase (DAAO) inhibitor for PET imaging

Selective DAAO inhibitors have demonstrated promising therapeutic effects in clinical studies, including clinically alleviating symptoms of schizophrenic patients and ameliorating cognitive function in Alzheimer’s patients with early phase. Herein we report the synthesis and preliminary evaluation o...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Deng, Xiaoyun, Zhang, Yiding, Chen, Zhen, Kumata, Katsushi, Van, Richard, Rong, Jian, Shao, Tuo, Hatori, Akiko, Mori, Wakana, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Wey, Hsiao-Ying, Shao, Yihan, Josephson, Lee, Murtas, Giulia, Pollegioni, Loredano, Zhang, Ming-Rong, Liang, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363051/
https://ncbi.nlm.nih.gov/pubmed/32631531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2020.127326
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