Synthesis and evaluation of [(11)C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain

BACKGROUND: Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [(11)C]MMPIP, a putative radioligand for mGlu7 (binding constant K(B) = 30 nM), and evaluated its po...

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Bibliografiske detaljer
Main Authors: Yamasaki, Tomoteru, Kumata, Katsushi, Yui, Joji, Fujinaga, Masayuki, Furutsuka, Kenji, Hatori, Akiko, Xie, Lin, Ogawa, Masanao, Nengaki, Nobuki, Kawamura, Kazunori, Zhang, Ming-Rong
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2013
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751550/
https://ncbi.nlm.nih.gov/pubmed/23870677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-3-54
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