Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([(11)C]MPPO) based on α-ketoheterocyclic scaffold

Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (eCB) signaling. Selective pharmacological blockade of FAAH has emerged as a potential therapy to discern the endogenous...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Wang, Lu, Yui, Joji, Wang, Qifan, Zhang, Yiding, Mori, Wakana, Shimoda, Yoko, Fujinaga, Masayuki, Kumata, Katsushi, Yamasaki, Tomoteru, Hatori, Akiko, Rotstein, Benjamin H., Collier, Thomas Lee, Ran, Chongzhao, Vasdev, Neil, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876717/
https://ncbi.nlm.nih.gov/pubmed/26505525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00248
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