Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([(11)C]MPPO) based on α-ketoheterocyclic scaffold

Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (eCB) signaling. Selective pharmacological blockade of FAAH has emerged as a potential therapy to discern the endogenous...

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Bibliografiset tiedot
Julkaisussa:ACS Chem Neurosci
Päätekijät: Wang, Lu, Yui, Joji, Wang, Qifan, Zhang, Yiding, Mori, Wakana, Shimoda, Yoko, Fujinaga, Masayuki, Kumata, Katsushi, Yamasaki, Tomoteru, Hatori, Akiko, Rotstein, Benjamin H., Collier, Thomas Lee, Ran, Chongzhao, Vasdev, Neil, Zhang, Ming-Rong, Liang, Steven H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876717/
https://ncbi.nlm.nih.gov/pubmed/26505525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00248
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