Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([(11)C]MPPO) based on α-ketoheterocyclic scaffold

Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (eCB) signaling. Selective pharmacological blockade of FAAH has emerged as a potential therapy to discern the endogenous...

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Vydáno v:ACS Chem Neurosci
Hlavní autoři: Wang, Lu, Yui, Joji, Wang, Qifan, Zhang, Yiding, Mori, Wakana, Shimoda, Yoko, Fujinaga, Masayuki, Kumata, Katsushi, Yamasaki, Tomoteru, Hatori, Akiko, Rotstein, Benjamin H., Collier, Thomas Lee, Ran, Chongzhao, Vasdev, Neil, Zhang, Ming-Rong, Liang, Steven H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876717/
https://ncbi.nlm.nih.gov/pubmed/26505525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00248
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