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Synthesis and preliminary PET imaging studies of a FAAH radiotracer ([(11)C]MPPO) based on α-ketoheterocyclic scaffold

Fatty acid amide hydrolase (FAAH) is one of the principle enzymes for metabolizing endogenous cannabinoid neurotransmitters such as anandamide, and thus regulates endocannabinoid (eCB) signaling. Selective pharmacological blockade of FAAH has emerged as a potential therapy to discern the endogenous...

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發表在:ACS Chem Neurosci
Main Authors: Wang, Lu, Yui, Joji, Wang, Qifan, Zhang, Yiding, Mori, Wakana, Shimoda, Yoko, Fujinaga, Masayuki, Kumata, Katsushi, Yamasaki, Tomoteru, Hatori, Akiko, Rotstein, Benjamin H., Collier, Thomas Lee, Ran, Chongzhao, Vasdev, Neil, Zhang, Ming-Rong, Liang, Steven H.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876717/
https://ncbi.nlm.nih.gov/pubmed/26505525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00248
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