Development of a highly-specific (18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been associated with multiple CNS disorders and symptom...

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Publicado en:Acta Pharm Sin B
Autores principales: Chen, Zhen, Mori, Wakana, Rong, Jian, Schafroth, Michael A., Shao, Tuo, Van, Richard S., Ogasawara, Daisuke, Yamasaki, Tomoteru, Hiraishi, Atsuto, Hatori, Akiko, Chen, Jiahui, Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Sun, Jiyun, Yu, Qingzhen, Collier, Thomas L., Shao, Yihan, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8245801/
https://ncbi.nlm.nih.gov/pubmed/34221877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2021.01.021
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