Synthesis and Preclinical Evaluation of Sulfonamido-based [(11)C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase

Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system. Inhibition of MAGL is not only of interest for probing the cannabinoid pathway but also as a therapeutic...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Wang, Lu, Mori, Wakana, Cheng, Ran, Yui, Joji, Hatori, Akiko, Ma, Longle, Zhang, Yiding, Rotstein, Benjamin H., Fujinaga, Masayuki, Shimoda, Yoko, Yamasaki, Tomoteru, Xie, Lin, Nagai, Yuji, Minamimoto, Takafumi, Higuchi, Makoto, Vasdev, Neil, Zhang, Ming-Rong, Liang, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4893642/
https://ncbi.nlm.nih.gov/pubmed/27279908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.15257
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