Design, Synthesis and Evaluation of (18)F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) li...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Chen, Zhen, Mori, Wakana, Fu, Hualong, Schafroth, Michael A., Hatori, Akiko, Shao, Tuo, Zhang, Genwei, Van, Richard S., Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Wang, Lu, Belov, Vasily, Ogasawara, Daisuke, Giffenig, Pilar, Deng, Xiaoyun, Rong, Jian, Yu, Qingzhen, Zhang, Xiaofei, Papisov, Mikhail I., Shao, Yihan, Collier, Thomas L., Ma, Jun-An, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875603/
https://ncbi.nlm.nih.gov/pubmed/31518130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00936
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