Design, Synthesis and Evaluation of (18)F-labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) li...

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發表在:J Med Chem
Main Authors: Chen, Zhen, Mori, Wakana, Fu, Hualong, Schafroth, Michael A., Hatori, Akiko, Shao, Tuo, Zhang, Genwei, Van, Richard S., Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Wang, Lu, Belov, Vasily, Ogasawara, Daisuke, Giffenig, Pilar, Deng, Xiaoyun, Rong, Jian, Yu, Qingzhen, Zhang, Xiaofei, Papisov, Mikhail I., Shao, Yihan, Collier, Thomas L., Ma, Jun-An, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875603/
https://ncbi.nlm.nih.gov/pubmed/31518130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00936
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