Design, synthesis and evaluation of reversible and irreversible monoacylglycerol lipase positron emission tomography (PET) tracers using a ‘tail switching’ strategy on a piperazinyl azetidine skeleton

Monoacylglycerol lipase (MAGL) is a serine hydrolase that degrades 2-arachidonoylglycerol (2-AG) in the endocannabinoid system (eCB). Selective inhibition of MAGL has emerged as a potential therapeutic approach for the treatment of diverse pathological conditions including chronic pain, inflammation...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Chen, Zhen, Mori, Wakana, Deng, Xiaoyun, Cheng, Ran, Ogasawara, Daisuke, Zhang, Genwei, Schafroth, Michael A., Dahl, Kenneth, Fu, Hualong, Hatori, Akiko, Shao, Tuo, Zhang, Yiding, Yamasaki, Tomoteru, Zhang, Xiaofei, Rong, Jian, Yu, Qingzhen, Hu, Kuan, Fujinaga, Masayuki, Xie, Lin, Kumata, Katsushi, Gou, Yuancheng, Chen, Jingjin, Gu, Shuyin, Bao, Liang, Wang, Lu, Lee Collier, Thomas, Vasdev, Neil, Shao, Yihan, Ma, Jun-An, Cravatt, Benjamin F., Fowler, Christopher, Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581563/
https://ncbi.nlm.nih.gov/pubmed/30829483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01778
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