Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

Gasdermin D (GsdmD) was recently identified as the executioner of pyroptotic inflammatory cell death, and is a substrate for caspases-1 and 11. GsdmD is detrimental in lethal endotoxemia but protective in bacterial sepsis. However, little is known about its role during noninfectious/sterile injuries...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Yang, Chenxuan, Sun, Ping, Deng, Meihong, Loughran, Patricia, Li, Wenbo, Yi, Zhongjie, Li, Shilai, Zhang, Xianghong, Fan, Jie, Billiar, Timothy R., Scott, Melanie J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579760/
https://ncbi.nlm.nih.gov/pubmed/31209224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1719-6
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