Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

BACKGROUND AND AIMS: Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its anti‐inflammatory roles have been shown to be mediated by the modulation of oxidative stress, an important mechanism of hepatic...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Yi, Zhongjie, Deng, Meihong, Scott, Melanie J., Fu, Guang, Loughran, Patricia A., Lei, Zhao, Li, Shilai, Sun, Ping, Yang, Chenxuan, Li, Wenbo, Xu, Hongbo, Huang, Feizhou, Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702080/
https://ncbi.nlm.nih.gov/pubmed/31997373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31147
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