Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

BACKGROUND AND AIMS: Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its anti‐inflammatory roles have been shown to be mediated by the modulation of oxidative stress, an important mechanism of hepatic...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Hepatology
Päätekijät: Yi, Zhongjie, Deng, Meihong, Scott, Melanie J., Fu, Guang, Loughran, Patricia A., Lei, Zhao, Li, Shilai, Sun, Ping, Yang, Chenxuan, Li, Wenbo, Xu, Hongbo, Huang, Feizhou, Billiar, Timothy R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702080/
https://ncbi.nlm.nih.gov/pubmed/31997373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31147
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