Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury

BACKGROUND AND AIMS: Itaconate, a metabolite of the tricarboxylic acid cycle, plays anti‐inflammatory roles in macrophages during endotoxemia. The mechanisms underlying its anti‐inflammatory roles have been shown to be mediated by the modulation of oxidative stress, an important mechanism of hepatic...

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Détails bibliographiques
Publié dans:Hepatology
Auteurs principaux: Yi, Zhongjie, Deng, Meihong, Scott, Melanie J., Fu, Guang, Loughran, Patricia A., Lei, Zhao, Li, Shilai, Sun, Ping, Yang, Chenxuan, Li, Wenbo, Xu, Hongbo, Huang, Feizhou, Billiar, Timothy R.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702080/
https://ncbi.nlm.nih.gov/pubmed/31997373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31147
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