Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

Dysregulation of T cell apoptosis contributes to the pathogenesis of acute systemic inflammation–induced immunosuppression, as seen in sepsis and trauma. However, the regulatory mechanisms of T cell apoptosis are unclear. Activation of stimulator of interferon genes (STING) has been shown to induce...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Long, Junke, Yang, Chenxuan, Zheng, Yawen, Loughran, Patricia, Guang, Fu, Li, Yiming, Liao, Hong, Scott, Melanie J., Tang, Daolin, Billiar, Timothy R., Deng, Meihong
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531880/
https://ncbi.nlm.nih.gov/pubmed/32967837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5447
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