Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding

BACKGROUND: Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the intracellular role of HMGB1 in hepatocellular steatosis is unknown. Therefore,...

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Detalhes bibliográficos
Publicado no:Mol Med
Main Authors: Lin, Minjie, Long, Jungke, Li, Wenbo, Yang, Chenxuan, Loughran, Patricia, O’Doherty, Robert, Billiar, Timothy R., Deng, Meihong, Scott, Melanie J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687718/
https://ncbi.nlm.nih.gov/pubmed/33238880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00227-6
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