Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet

We showed previously that UBXD8 plays a key role in proteasomal degradation of lipidated ApoB in hepatocarcinoma cell lines. In the present study, we aimed to investigate the functions of UBXD8 in liver in vivo. For this purpose, hepatocyte-specific UBXD8 knockout (UBXD8-LKO) mice were generated. Th...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Imai, Norihiro, Suzuki, Michitaka, Hayashi, Kazuhiko, Ishigami, Masatoshi, Hirooka, Yoshiki, Abe, Takaya, Shioi, Go, Goto, Hidemi, Fujimoto, Toyoshi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430229/
https://ncbi.nlm.nih.gov/pubmed/25970332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127114
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