LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of lethality when released extracellularly during sepsis. The major source of circulating HMGB1 in sepsis is hepatocytes. However, the mechanism of HMGB1 release of hepatocytes during sepsis is not very clear. W...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Li, Wenbo, Deng, Meihong, Loughran, Patricia A., Yang, Muqing, Lin, Minjie, Yang, Chenxuan, Gao, Wentao, Jin, Shuqing, Li, Shilai, Cai, Jingjing, Lu, Ben, Billiar, Timothy R., Scott, Melanie J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160675/
https://ncbi.nlm.nih.gov/pubmed/32328059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00229
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