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Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
Inflammatory caspases, such as caspase-1 and -11, mediate innate immune detection of pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death, and specifically defends against bacterial pathogens that invade the cytosol. During endotoxemia, however, excessive caspase-11 activation c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3931427/ https://ncbi.nlm.nih.gov/pubmed/24031018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1240988 |
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