Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin d. Hematopoietic cells produced MyD88- and TRIF-dependent inflammatory cytokines sufficient to initiate shoc...

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Bibliografiska uppgifter
I publikationen:Immunity
Huvudupphovsmän: Mandal, Pratyusha, Feng, Yanjun, Lyons, John D., Berger, Scott B., Otani, Shunsuke, DeLaney, Alexandra, Tharp, Gregory K., Maner-Smith, Kristal, Burd, Eileen M., Schaeffer, Michelle, Hoffman, Sandra, Capriotti, Carol, Roback, Linda, Young, Cedrick B., Liang, Zhe, Ortlund, Eric A., DiPaolo, Nelson C., Bosinger, Steven, Bertin, John, Gough, Peter J., Brodsky, Igor E., Coopersmith, Craig M., Shayakhmetov, Dmitry M., Mocarski, Edward S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064639/
https://ncbi.nlm.nih.gov/pubmed/30021146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.011
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