Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin d. Hematopoietic cells produced MyD88- and TRIF-dependent inflammatory cytokines sufficient to initiate shoc...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Immunity
Main Authors: Mandal, Pratyusha, Feng, Yanjun, Lyons, John D., Berger, Scott B., Otani, Shunsuke, DeLaney, Alexandra, Tharp, Gregory K., Maner-Smith, Kristal, Burd, Eileen M., Schaeffer, Michelle, Hoffman, Sandra, Capriotti, Carol, Roback, Linda, Young, Cedrick B., Liang, Zhe, Ortlund, Eric A., DiPaolo, Nelson C., Bosinger, Steven, Bertin, John, Gough, Peter J., Brodsky, Igor E., Coopersmith, Craig M., Shayakhmetov, Dmitry M., Mocarski, Edward S.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064639/
https://ncbi.nlm.nih.gov/pubmed/30021146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.011
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares