Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock

The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic caspase-11 and gasdermin d. Hematopoietic cells produced MyD88- and TRIF-dependent inflammatory cytokines sufficient to initiate shoc...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Mandal, Pratyusha, Feng, Yanjun, Lyons, John D., Berger, Scott B., Otani, Shunsuke, DeLaney, Alexandra, Tharp, Gregory K., Maner-Smith, Kristal, Burd, Eileen M., Schaeffer, Michelle, Hoffman, Sandra, Capriotti, Carol, Roback, Linda, Young, Cedrick B., Liang, Zhe, Ortlund, Eric A., DiPaolo, Nelson C., Bosinger, Steven, Bertin, John, Gough, Peter J., Brodsky, Igor E., Coopersmith, Craig M., Shayakhmetov, Dmitry M., Mocarski, Edward S.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064639/
https://ncbi.nlm.nih.gov/pubmed/30021146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.06.011
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