Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock

Sepsis is a life-threating multi-organ disease induced by host innate immunity to pathogen-derived endotoxins including lipopolysaccharide (LPS). Direct sensing of LPS by caspase-11 activates inflammasomes and causes lethal sepsis in mice. Inhibition of caspase-11 inflammasomes is important for the...

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Pubblicato in:Front Immunol
Autori principali: Sakaguchi, Naoya, Sasai, Miwa, Bando, Hironori, Lee, Youngae, Pradipta, Ariel, Ma, Ji Su, Yamamoto, Masahiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522336/
https://ncbi.nlm.nih.gov/pubmed/33042141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.561948
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