LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling

High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of lethality when released extracellularly during sepsis. The major source of circulating HMGB1 in sepsis is hepatocytes. However, the mechanism of HMGB1 release of hepatocytes during sepsis is not very clear. W...

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Pubblicato in:Front Immunol
Autori principali: Li, Wenbo, Deng, Meihong, Loughran, Patricia A., Yang, Muqing, Lin, Minjie, Yang, Chenxuan, Gao, Wentao, Jin, Shuqing, Li, Shilai, Cai, Jingjing, Lu, Ben, Billiar, Timothy R., Scott, Melanie J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160675/
https://ncbi.nlm.nih.gov/pubmed/32328059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00229
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