Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding

BACKGROUND: Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the intracellular role of HMGB1 in hepatocellular steatosis is unknown. Therefore,...

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Gepubliceerd in:Mol Med
Hoofdauteurs: Lin, Minjie, Long, Jungke, Li, Wenbo, Yang, Chenxuan, Loughran, Patricia, O’Doherty, Robert, Billiar, Timothy R., Deng, Meihong, Scott, Melanie J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687718/
https://ncbi.nlm.nih.gov/pubmed/33238880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00227-6
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