Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies

The fusion peptide (FP) of HIV-1 envelope glycoprotein (Env) is essential for mediating viral entry. Detection of broadly neutralizing antibodies (bnAbs) that interact with the FP has revealed it as a site of vulnerability. We delineate X-ray and cryo-electron microscopy (cryo-EM) structures of bnAb...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Yuan, Meng, Cottrell, Christopher A., Ozorowski, Gabriel, van Gils, Marit J., Kumar, Sonu, Wu, Nicholas C., Sarkar, Anita, Torres, Jonathan L., de Val, Natalia, Copps, Jeffrey, Moore, John P., Sanders, Rogier W., Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579543/
https://ncbi.nlm.nih.gov/pubmed/31194940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.04.011
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