Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the pre-fusion conformation of the gp41 protein on cleaved Envelope trimers

Broadly neutralizing antibodies to HIV are much sought-after (a) to guide vaccine design, both as templates and to inform on the authenticity of vaccine candidates, (b) to assist in structural studies and (c) as potential therapeutics. However, the number of targets on the viral envelope spike for s...

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Main Authors: Falkowska, Emilia, Le, Khoa M., Ramos, Alejandra, Doores, Katie J., Lee, Jeong Hyun, Blattner, Claudia, Ramirez, Alejandro, Derking, Ronald, van Gils, Marit J., Liang, Chi-Hui, Mcbride, Ryan, von Bredow, Benjamin, Shivatare, Sachin S., Wu, Chung-Yi, Chan-Hui, Po-Ying, Liu, Yan, Feizi, Ten, Zwick, Michael B., Koff, Wayne C., Seaman, Michael S., Swiderek, Kristine, Moore, John P., Evans, David, Paulson, James C., Wong, Chi-Huey, Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Poignard, Pascal, Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070425/
https://ncbi.nlm.nih.gov/pubmed/24768347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.04.009
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