Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function

Nitroxyl (HNO) positively modulates myocardial function by accelerating Ca(2+) reuptake into the sarcoplasmic reticulum (SR). HNO-induced enhancement of myocardial Ca(2+) cycling and function is due to the modification of cysteines in the transmembrane domain of phospholamban (PLN), which results in...

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Publicat a:J Gen Physiol
Autors principals: Keceli, Gizem, Majumdar, Ananya, Thorpe, Chevon N., Jun, Seungho, Tocchetti, Carlo G., Lee, Dong I., Mahaney, James E., Paolocci, Nazareno, Toscano, John P.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571998/
https://ncbi.nlm.nih.gov/pubmed/30842219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812208
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